Due to the high clinical variability in presentation of Déjerine-Roussy syndrome, it is impossible to predict which patients with a thalamic stroke will develop pain. Stroke and pain can sometimes result in Dejerine-Roussy syndrome. Available treatments include antidepressants, anticonvulsants, and. Improvement in neurological signs and symptoms of thalamic syndrome ( Dejerine-Roussy Syndrome) due to a stroke 20 years previously (in.

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This provides indirect evidence for the damage of central neurons from N-methyl-D-aspartate-receptor activation in central sensitization. Weeks to months later, numbness can develop into severe and chronic pain that is not proportional to an environmental stimulus, called dysesthesia or allodynia. As ablation of any area of the brain might cause other deficits or even aggravates the pain. Brain herniation Reye’s Hepatic encephalopathy Toxic encephalopathy Hashimoto’s encephalopathy.

Encephalitis Viral encephalitis Herpesviral encephalitis Limbic encephalitis Encephalitis lethargica Cavernous sinus thrombosis Brain abscess Amoebic.

Please review our privacy policy. Supportive care, rehabilitation, and psychotherapy are recommended as well. Dejerine-Roussy syndrome Thalamic pain syndrome. This pain is a sharp, burning, and stabbing pain with the intensity of somewhere between 3 to 6 on a numeric rating scale of 0 to 10 10 being the worst pain imaginablealong with hyperalgesia and allodynia.


Some areas of the body may be more intensely affected than other areas. Incidence of central post-stroke pain. Later on, the disorder came to be labelled Dejerine-Roussy syndrome after the two French neurologists who described the so-called thalamic syndromewhich dwjerine a pain component.

Treatment Treatment for central pain syndrome remains unsatisfactory in that, although most patients find some relief, complete control remains infrequent. Rouwsy ataxia Tabes dorsalis motor: The incidence and duration of central post-stroke pain are not related to gender or age of the patient nor the side of the lesion.

Antiplatelet medications especially cilostazol may have a role in the treatment of central post-stroke pain. Various Invasive and Non-Invasive Non-Pharmacological Techniques The following are available for managing the patients but have variable efficacy.

The ruossy of the pain also varies considerably, and can affect a large part of the contralateral body or a smaller portion depending on the exact size and location dejerkne the thalamic lesion The thalamus is generally believed to relay sensory information between a variety of subcortical areas and the cerebral cortex. This is an experimental avenue that awaits human trials.

Dejerine–Roussy syndrome

Gabapentin is effective for both central or peripheral origin neuropathic pain, with an optimal daily dose of mg. Dejerine J, Roussy G.

Brain magnetic resonance imaging MRI of patients with this syndrome has shown infarctions, while single-photon emission computed tomography shows decreased dekerine flow, especially to the left thalamus.


Because the pain is mostly unchanging after development, many patients test different medications and eventually choose the regimen that best adapts to their lifestyle, the most common of which are orally and intravenously administered.

Dejerine–Roussy syndrome – Wikipedia

Two drugs, amitriptyline and lamotrigine, have proven beneficial in controlled trials, especially for individuals with central pain of brain origin. Motor neuron disease mixed: Traditional pain medications e. Intravenously-infused tramadol was found effective in patients with chronic central poststroke pain. NSAIDs generally provide little to no relief for individuals with central pain syndrome. Affected skin may be extremely sensitive to touch and to hot or cold temperatures cutaneous hypersensitivity.

Long-term use may cause weight gain. Unsourced material may be challenged and removed.

Dejerine-Roussy Syndrome

Edit article Share article View revision history. Ward M, Mammis A. Additionally, therapies that have proven beneficial in some individuals may have no benefit in others. Thereafter, and up until recently, central pain became synonymous with thalamic pain syndrome.