BAKER VENKATARAMAN REARRANGEMENT PDF

Benz[b]indeno[2,1-e]pyran,dione 1a and analogues have been prepared and studied for enhancing the biosynthesis of erythropoietin. The scope of the Baker–Venkataraman rearrangement is illustrated by way of numerous examples of its application, and in doing so, the review contains over. This rearrangement reaction proceeds via enolate formation followed by acyl transfer. It is named after the scientists Wilson Baker and K. Venkataraman.

Author: Murr Vokasa
Country: Great Britain
Language: English (Spanish)
Genre: Relationship
Published (Last): 15 April 2009
Pages: 253
PDF File Size: 3.48 Mb
ePub File Size: 15.54 Mb
ISBN: 773-4-95570-915-5
Downloads: 17775
Price: Free* [*Free Regsitration Required]
Uploader: Sanos

Views Read Edit View history. Name reactions Revolvy Brain revolvybrain. Kostanecki acylation topic The Kostanecki acylation is a method used in organic synthesis to form chromones[1] or coumarins[2] by acylation of O-hydroxyaryl ketones with aliphatic acid anhydrides, followed by cyclization. Total synthesis by carbamoyl Baker-Venkataraman rearrangement and structural revision to isoeugenetin methyl ether”. Member feedback about Nucleophilic acyl substitution: The fifth step shows the nucleophilic hydroxide attacking the carbonyl carbon to create a new six membered heterocyclic ring.

This rearrangement reaction proceeds via enolate formation followed by acyl transfer. Organic reactions Revolvy Brain revolvybrain. This was commonly afforded by treatment with strong acid Nucleophilic acyl substitution describe a class of substitution reactions involving nucleophiles and acyl compounds.

Well-known reactions and reagents in organic chemistry include 1,3-Dipolar cycloaddition rearrangemet rearrangement A Abramovitch—Shapiro tryptamine synthesis Acetalisation Acetoacetic ester condensation Achmatowicz reaction Acylation Acyloin condensation Adams catalyst Adams decarboxylation Adkins catalyst Adkins—Peterson reaction Akabori amino acid reaction Alcohol oxidation Alder ene reaction Alder—Stein rules Aldol addition Aldol condensation Algar—Flynn—Oyamada reaction Alkylimino-de-oxo-bisubstitution Alkyne trimerisation Alkyne zipper reaction Allan—Robinson reaction Allylic rearrangement Amadori rearrangement Amine alkylation Angeli—Rimini reaction Andrussov oxidation Appel reaction Arbuzov reaction, Arbusow reaction Arens—van Dorp synthesis, Isler modification Aromatic nitration Arndt—Eistert synthesis Auwers synthesis Azo coupling B Baeyer—Drewson indigo synthesis Baeyer—Villiger oxidation Baeyer—Villiger rearrangement Bakeland process Bakelite This page was last edited on 28 Augustat The cyclic intermediate is opened up to form a more stable phenolatewhich is protonated during acidic work-up to give the desired product.

  CHROMAGE DUR PDF

The Baker—Venkataraman rearrangement is often used in the synthesis of chromones and flavones.

Baker–Venkataraman rearrangement – Wikipedia

Outline of organic chemistry topic The venkaatraman outline is provided as an overview of and topical guide to organic chemistry: The Baker—Venkataraman rearrangement is the chemical reaction of 2-acetoxyacetophenones with base to form 1,3-di ketones. Venkataraman Ramaswamy Venkataraman, —Indian lawyer, independence activist and politician, President of India —92 S.

Organic chemistry — scientific study of the structure, properties, composition, reactions, and preparation by synthesis or by other means of carbon-based compounds, hydrocarbons, and their derivatives. After the base-catalyzed rearrangement, treatment with acid generally affords the chromone or flavone core, though other milder methods have been reported.

Rearrangement reactions Name reactions. Venkataraman topic Venkataraman, Venkatraman and Venkitaraman are names of Indian origin, used both as family names and as masculine given names. The following outline is provided as an overview of and topical guide to organic chemistry: The Kostanecki acylation is a method used in organic synthesis to form chromones[1] or coumarins[2] by acylation of O-hydroxyaryl ketones with aliphatic acid anhydrides, followed by cyclization.

Because acyl derivatives react with a wide variety of nucleophiles, and because the product rerarangement depend on the particular type of acyl derivative and cenkataraman involved, nucleophilic acyl substitution reactions can be used to synthesize a variety of different products. Mechanism The mechanism consists of three well-differentiated reactions: The Allan—Robinson reaction is the chemical reaction venkwtaraman o-hydroxyaryl ketones with aromatic rearramgement to form flavones or isoflavones.

A base abstracts the hydrogen atom alpha to the aromatic ketoneforming an enolate.

  FLYGT 3152 PDF

It is named rearrangemeht the scientists Wilson Baker and K. To complete the construction of the chromone or flavone core, cyclodehydration is required.

Action of sodamide on 1-acyloxyacetonaphthones”. People with those names include: A base abstracts the hydrogen atom alpha to the aromatic ketoneforming an enolate. Regiospecific route to substituted 4-hydroxycoumarins”.

Member feedback about Venkataraman: Member feedback about Krishnasami Venkataraman: Member feedback about Outline of organic chemistry: Flavones Revolvy Brain revolvybrain. Family name Ashok Venkitaraman born beforeBritish cancer researcher C. Retrieved from ” https: A Valid Scaffold in Medicinal Chemistry”. Then, the enolate attacks the ester carbonyl to form a cyclic alkoxide. This was commonly afforded by treatment with strong acid, however many milder conditions have now been developed.

Baker–Venkataraman rearrangement

As a result the resulting carboxylate attacks an alpha hydrogen to create the enol functionality again in step four. Carbamoyl rendition of the Baker-Venkataraman rearrangement. Organic chemistry Revolvy Brain revolvybrain peptide Lailakafu. The Baker—Venkataraman rearrangement is the chemical reaction of 2-acetoxyacetophenones with base to form 1,3-di ketones.

Baker-Venkataraman Rearrangement

In other projects Wikimedia Commons. See Kostanecki acylation Reaction Overview Mechanism The first step is an enolization which is a rwarrangement transfer created a hydroxide instead of a carbonyl and an alkene instead of an alkane. In this type of reaction, a nucleophile — such as an alcohol, amine, or enolate — displaces the leaving group of an acyl derivative — such as an acid halide, anhydride, or ester.